Protective and therapeutic effects of glyprolines in psychoemotional stress induced by cholecystokinin-4 injection.

Autor: S. Edeeva, G. Kopylova, Z. Bakaeva, G. Samonina, B. Umarova, A. Guseva
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Zdroj: Bulletin of Experimental Biology & Medicine; Mar2008, Vol. 145 Issue 3, p302-306, 5p
Abstrakt: Abstract  Experiments on outbred albino male rats showed that psychoemotional stress induced by intraperitoneal injection of cholecystokinin-4 (100 µg/kg) increased anxiety, impaired orientation and exploration activities in the elevated plus-maze and hole-board tests, and increased the level of depression of Porsolt test. Preliminary intranasal administration of glyprolines (15 min before cholecystokinin) in a dose of 3.7 µmol/kg prevented the development of stress-induced behavioral disturbances. Administration of peptides 30 min after cholecystokinin-4, i.e. to rats with developed behavioral disturbances, almost completely abolished these disturbances. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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