| Autor: |
Nerome, Yasuhito, Imanaka, Hiroyuki, Nonaka, Yukiko, Takei, Syuji, Kawano, Yoshifumi |
| Předmět: |
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| Zdroj: |
Pediatrics International; Aug2008, Vol. 50 Issue 4, p541-545, 5p, 2 Charts, 5 Graphs |
| Abstrakt: |
Background: Pediatricians use corticosteroids for prolonged periods of time for the treatment of many diseases, including rheumatic disease. The side-effects of corticosteroids, especially cataracts, are widely recognized, but the predictive risk factors for steroid-induced cataracts have not yet been fully characterized. Methods: The relationship between the formation of cataracts and steroid therapy was evaluated in patients with rheumatic disease. Results: The initiation of steroid therapy in children under 12 years of age ( P = 0.041) and i.v. methylprednisone pulse therapy (IVMP) ( P = 0.046) are significant risk factors for inducing cataracts. In contrast, the cumulative corticosteroid dose, sex, and daily corticosteroid dose were not associated with cataract formation. Conclusions: Younger children, who need frequent IVMP to treat their rheumatic diseases, should be examined by ophthalmologists frequently to avoid developing amblyopia from cataracts. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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