| Autor: |
Hearn, Donald W., Mondaini, Rubem P., Pardalos, Panos M., Floudas, Christodoulos A., Fung, Ho Ki, Morikis, Dimitrios, Taylor, Martin S., Zhang, Li |
| Zdroj: |
Mathematical Modelling of Biosystems; 2008, p133-183, 51p |
| Abstrakt: |
De novo protein design is initiated with a postulated or known flexible threedimensional protein structure and aims at identifying amino acid sequences compatible with such a structure. The problem was first denoted as the "inverse folding problem" [4, 5] since protein design has intimate links to the well-known protein folding problem [6]. While the protein folding problem aims at determining the single structure for a sequence, the de novo protein design problem exhibits a high level of degeneracy; that is, a large number of sequences are always found to share a common fold, although the sequences will vary with respect to properties such as activity and stability. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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