| Autor: |
Estey, E. H., Faderl, S. H., Kantarjian, H. M., Thomas, Xavier, Fiere, Denis |
| Zdroj: |
Acute Leukemias; 2008, p145-159, 15p |
| Abstrakt: |
The GET-LALA (Groupe d‘Etude et de Traitement de la Leucémie Aiguë Lymphoblastique de l'Adulte) group has performed a series of studies evaluating different aspects of remission induction and postremission treatment in adults with acute lymphoblastic leukemia (ALL). The LALA group was formed by interested hematologists, physicians, and statisticians in the beginning of the 1980s. The first working party was set up in 1982 with Professor Denis Fiere as chairman of the Steering Committee, and the first randomized trial involving multiple French centers was started in 1983. Since then several other trials have been opened to persons over 15 years of age. In recent years, clinical trials have been supplemented by systematic morphologic, immunophenotyping, cytogenetic, and molecular genetic studies leading to the identification of different risk groups of patients who may warrant individualized treatments. With the development of data managing and the establishment of a large network of collaborating physicians and biologists, the later trials became larger, and reporting was more reliable. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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