| Autor: |
Seenath, M. M., Roberts, D., Cawthorne, C., Saunders, M. P., Armstrong, G. R., O'Dwyer, S. T., Stratford, I. J., Dive, C., Renehan, A. G. |
| Předmět: |
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| Zdroj: |
British Journal of Cancer; 8/5/2008, Vol. 99 Issue 3, p459-463, 5p, 1 Color Photograph, 1 Graph |
| Abstrakt: |
Hypoxia inducible factor 1 (HIF-1) represses the transcription of pro-apoptotic bid in colorectal cancer cells in vitro. To assess the clinical relevance of this observation, HIF-1alpha and Bid were assessed in serial sections of 39 human colorectal adenocarcinomas by immunohistochemistry. In high HIF-1alpha nuclear-positive cell subpopulations, there was a significant reduction in Bid expression (ANOVA, P=0.04). Given the role of Bid in drug-induced apoptosis, these data add impetus to strategies targeting HIF-1 for therapeutic gain. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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