Serum Pro-hepcidin Levels in Rheumatoid Arthritis and Systemic Lupus Erythematosus.

Autor: Ahmet Isik, Bilal Ustundag, Kerem Metin, Kader Aksoy
Předmět:
Zdroj: Inflammation; Jun2008, Vol. 31 Issue 3, p146-153, 8p, 4 Charts
Abstrakt: Abstract  Hepcidin is a principal iron regulatory hormone and its expression is stimulated by cytokines. The aim of this study was to determine serum levels of the prohormone form of hepcidin, pro-hepcidin, in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The study included 72 RA and 28 SLE patients and 33 healthy controls (HC). Serum iron status, tumor necrosis factor (TNF)-α, interleukin (IL)-6 and pro-hepcidin levels were determined. Pro-hepcidin levels in the RA group was higher than SLE and HC groups (p p r = 0.459, p r = 0.374, p r = −0.603, p  [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index