| Autor: |
Uwe Langsenlehner, Gerald Wolf, Tanja Langsenlehner, Armin Gerger, Günter Hofmann, Heimo Clar, Thomas Wascher, Bernhard Paulweber, Hellmut Samonigg, Peter Krippl, Wilfried Renner |
| Předmět: |
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| Zdroj: |
Breast Cancer Research & Treatment; May2008, Vol. 109 Issue 2, p297-304, 8p, 2 Diagrams, 6 Charts |
| Abstrakt: |
Abstract Purpose Vascular endothelial growth factor (VEGF) is a key regulator of tumor-induced angiogenesis and is required for growth of tumors. We tested the hypothesis that VEGF gene polymorphisms may be associated with breast cancer. Experimental design We performed a case–control study including 804 female incident breast cancer patients and 804 female age-matched healthy control subjects. We selected seven VEGF candidate polymorphisms and determined genotypes by 5′-nuclease (TaqMan) assays. Furthermore, VEGF plasma levels and genotypes were analyzed in a group of 81 healthy volunteers (64 men and 17 women). Results Haplotype analysis showed two separate blocks of high-linkage disequilibrium, formed by five polymorphisms upstream of the coding sequence (promoter and 5′ untranslated region) and two polymorphisms downstream of the coding sequence. None of the single polymorphisms or haplotypes was significantly associated with the presence of breast cancer. After Bonferroni correction for multiple testing, only one statistical signifcant association between VEGF genotypes and haplotypes and tumor characteristics was observed (-634C allele and small tumor size; p Conclusions Our findings do not support the hypothesis that VEGF polymorphisms are associated with breast cancer risk. The association of the VEGF -634C allele with small tumor size is in clear contrast to a previous publication and should be interpreted with caution until replicated by additional studies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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