| Autor: |
Stock, G., Lessl, M., Wohlleben, W., Spellig, T., Müller-Tiemann, B., Dürfahrt, T., Marahiel, M. A. |
| Zdroj: |
Biocombinatorial Approaches for Drug Finding; 2005, p79-106, 28p |
| Abstrakt: |
For the development and production of pharmacologically important compounds based on natural scaffolds simple and effective techniques that can combine chemistry, genetics and molecular biology are indispensable. The NRPSs can provide such interesting tools to generate and modify novel products. The recently gained structural and mechanistic information on NRPSs have made this class of multienzymes a powerful native tool box that would help to achieve this goal. Rearrangements of domains and modules in combination with the elucidation of chemoenzymatic reactions highly increases the potential of these special enzymes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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