| Autor: |
Beitler, Jonathan J., Garg, Madhur, Owen, Randall P., Sarta, Catherine, Smith, Richard V., Yaparpalvi, Ravindra |
| Předmět: |
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| Zdroj: |
Head & Neck; Jul2008, Vol. 30 Issue 7, p933-938, 6p, 2 Charts, 3 Graphs |
| Abstrakt: |
Background Regional control for advanced nodal disease has been only marginally affected by concurrent chemoradiation, hyperfractionation, concomitant boost, or accelerated external radiation. Methods Twenty-five necks in 24 patients received brachytherapy treatment (20 Gy in 10 twice-daily fractions) in addition to external radiation, neck dissection ± chemotherapy. Indications for brachytherapy included initial treatment of bulky disease (n = 12), recurrence of neck disease in a previously treated patient with at least a 3-month disease-free interval (n = 6), persistent disease after a curative efforts (n = 4), inadequate external radiation (ie, <40 Gy) due to either intolerance or noncompliance (n = 3). Results Overall actuarial regional control was 67% at 2 years. Regional control for those receiving brachytherapy as part of their initial treatment was 82% despite a mean nodal diameter of 8.7 cm (range, 5–15 cm). The 2-year actuarial regional control was 56% for the patients with a disease-free interval of at least 3 years. Conclusion High-dose-rate brachytherapy produced excellent regional control. © 2008 Wiley Periodicals, Inc. Head Neck, 2008 [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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