Dipeptidyl Peptidase-IV Inhibitors: Pharmacological Profile and Clinical Use.

Autor: White Jr., John R.
Předmět:
Zdroj: Clinical Diabetes; Spring2008, Vol. 26 Issue 2, p53-57, 5p, 1 Chart
Abstrakt: This article provides an overview of the pharmacology and clinical use of the dipeptidyl peptidase-IV (DPP-IV) inhibitors. It is claimed that these drugs inhibit the degradation of glucagon-like peptide-1 (GLP-1) in humans and cause some of the same effects of GLP-1, including stimulation of insulin secretion and inhibition of glucagon secretion. It is said that DPP-IV inhibitors offer a safe and effective method for modestly reducing hyperglycemia alone or in combination with other agents in patients with type 2 diabetes.
Databáze: Complementary Index