Corynebacterium glutamicum possesses two secA homologous genes that are essential for viability.

Autor:	Caspers, Michael, Freudl, Roland
Předmět:	CORYNEBACTERIUM GRAM-positive bacteria GENES MICROBIAL viability counts PLASMIDS PROTEINS GENOMES CORYNEBACTERIACEAE GENETIC vectors
Zdroj:	Archives of Microbiology; Jun2008, Vol. 189 Issue 6, p605-610, 6p, 1 Chart, 1 Graph
Abstrakt:	SecA is a central component of the bacterial Sec preprotein translocase. Besides the housekeeping SecA (SecA1), some mostly pathogenic Gram-positive bacteria possess an accessory SecA (SecA2) that is involved in the export of a few substrates only. Here we show that neither of the two secA homologous genes present in the genome of the non-pathogenic bacterium Corynebacterium glutamicum can be deleted, unless a copy of the respective gene is provided in trans on a plasmid. This finding is in marked contrast to all other cases examined so far making C. glutamicum the first reported bacterium possessing two essential SecA proteins. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Full text from SpringerLink