| Autor: |
Carlos Hernandez-Cassis, Anna Poniecka, Claudia K. Vogel, J. Maxwell McKenzie |
| Předmět: |
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| Zdroj: |
Thyroid; Mar2008, Vol. 18 Issue 3, p377-380, 4p |
| Abstrakt: |
Background:Ectopic intrathyroidal thymus tissue that forms mass lesions as a consequence of aberrant thymic migration during embryogenesis is rarely reported in the literature.Methods:We present the case of a 6-year-old boy with a right thyroid nodule and bilateral cervical lymph nodes. Thyroid hormone, antibodies, and routine chemistry tests were normal. Real-time thyroid ultrasound showed a right calcified nodule measuring 8 5 7 mm and multiple bilateral cervical lymph nodes. I131scan showed mild decreased uptake in the right upper lobe. On fine-needle aspiration biopsy we discovered an atypical lymphoid proliferation that was suspicious, although not diagnostic, of a lymphoma. Immunostain for calcitonin was negative. Flow cytometry of the thyroid nodule aspirate demonstrated an abnormal polyclonal T cell population with dual expression of CD4 and CD8, and a subpopulation of cells that expressed TdT suggesting the possibility of lymphoblastic lymphoma. DNA analysis, as well as polymerase chain reaction for T cell and B cell gene rearrangement, did not demonstrate changes in the gene for the heavy chain of immunoglobulin of B cells and gamma chain of the T cell receptor. Lymph node aspirate showed unremarkable T and B lymphoid cells.Main outcomes:The diagnosis of ectopic intrathyroidal thymus was made after the operation.Conclusion:Ectopic thymus tissue should be considered in the differential diagnosis of thyroid masses, especially in children. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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