| Autor: |
Bibl, Mirko, Mollenhauer, Brit, Esselmann, Hermann, Schneider, Michael, Lewczuk, Piotr, Welge, Volker, Gross, Martin, Falkai, Peter, Kornhuber, Johannes, Wiltfang, Jens |
| Předmět: |
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| Zdroj: |
Dementia & Geriatric Cognitive Disorders; 2008, Vol. 25 Issue 3, p256-265, 10p, 3 Charts, 4 Graphs |
| Abstrakt: |
Background/Aims: The study evaluated the patterns of cerebrospinal fluid (CSF), amyloid-β (Aβ) peptides, total tau and phospho-tau among Alzheimer’s disease (AD) and vascular dementias (VAD). Methods: Aβ-SDS-PAGE immunoblot and commercially available ELISAs were applied to the CSF analysis of 52 patients with probable (n = 21) and possible (n = 16) VAD, AD with cerebrovascular disease (n = 15), 30 patients with probable AD and 30 nondemented disease controls. Results: AD and AD with cerebrovascular disease displayed a similar neurochemical phenotype in contrast to nondemented disease controls and probable VAD with regard to tau, p-tau, Aβ1–40ox and Aβ1–42%. Possible VAD displayed AD-like changes only for Aβ1–40ox and Aβ1–42%. Conclusion: CSF neurochemical phenotypes sufficiently discriminate probable AD and VAD from each other, but their diagnostic value is limited in case of no clear-cut clinical appearance, such as possible VAD. Conversely, CSF Aβ peptides and p-tau levels may help estimate the involvement of AD-like pathophysiological pathways in VAD subgroups. Copyright © 2008 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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