| Autor: |
Fatehi-Hassanabad, Zahra, Chan, Catherine B. |
| Předmět: |
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| Zdroj: |
Nutrition & Metabolism; 2005, Vol. 2, p1-12, 12p, 2 Diagrams, 1 Chart |
| Abstrakt: |
Background: Optimal pancreatic β-cell function is essential for the regulation of glucose homeostasis in both humans and animals and its impairment leads to the development of diabetes. Type 2 diabetes is a polygenic disease aggravated by environmental factors such as low physical activity or a hypercaloric high-fat diet. Results: Free fatty acids represent an important factor linking excess fat mass to type 2 diabetes. Several studies have shown that chronically elevated free fatty acids have a negative effect on β-cell function leading to elevated insulin secretion basally but with an impaired response to glucose. The transcription factors PPARα, PPARγ and SREBP-1c respond to changing fat concentrations in tissues, thereby coordinating the genomic response to altered metabolic conditions to promote either fat storage or catabolism. These transcription factors have been identified in β-cells and it appears that each may exert influence on β-cell function in health and disease. Conclusion: The role of the PPARs and SREBP-1c as potential mediators of lipotoxicity is an emerging area of interest. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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