| Autor: |
Hatcher, N. G., Zhang, X., Stuart, J. N., Moroz, L. L., Sweedler, J. V., Gillette, R. |
| Předmět: |
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| Zdroj: |
Journal of Neurochemistry; Mar2008, Vol. 104 Issue 5, p1358-1363, 6p, 2 Graphs |
| Abstrakt: |
Serotonin (5-HT) is an intrinsic modulator of neural network excitation states in gastropod molluscs. 5-HT and related indole metabolites were measured in single, well-characterized serotonergic neurons of the feeding motor network of the predatory sea-slug Pleurobranchaea californica. Indole amounts were compared between paired hungry and satiated animals. Levels of 5-HT and its metabolite 5-HT-SO4 in the metacerebral giant neurons were observed in amounts approximately four-fold and two-fold, respectively, below unfed partners 24 h after a satiating meal. Intracellular levels of 5-hydroxyindole acetic acid and of free tryptophan did not differ significantly with hunger state. These data demonstrate that neurotransmitter levels and their metabolites can vary in goal-directed neural networks in a manner that follows internal state. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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