| Autor: |
La Rosa, Corinna, Krishnan, Aparna, Longmate, Jeff, Martinez, Joy, Manchanda, Pooja, Lacey, Simon F., Limaye, Ajit P., Diamond, Don J. |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 1/1/2008, Vol. 197 Issue 1, p25-33, 9p, 1 Chart, 4 Graphs |
| Abstrakt: |
Immunological parameters that distinguish solid-organ transplant (SOT) recipients at risk for life-threatening cytomegalovirus (CMV) disease are being actively pursued to aid posttransplant management. A candidate marker is programmed death (PD)-1 receptor, whose overexpression has been associated with disease progression during persistent viral infections. To determine whether levels of this negative regulator of T cell activity are altered in SOT recipients with symptoms of CMV disease, a comparative PD-1 expression analysis was done in healthy, CMV-positive individuals and in liver transplant recipients. PD-1 levels were measured among the total population of CD8+ and CD8+ T cells binding to CMV-specific major histocompatibility complex class I tetramers. Minimal PD-1 expression was found in the healthy, CMV-positive cohort, and symptomatic SOT recipients had significantly higher PD-1 levels. PD-1 up-regulation was significantly associated with incipient and overt CMV disease and with viremia. Our findings suggest that PD-1 could be developed as a prognostic tool to predict CMV disease and guide therapeutic interventions. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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