| Autor: |
Penis, Roy H., Purcell, Shaun, Fagerness, Jesen, Kirby, Andrew, Petryshen, Tracey L., Jinbo Fan, Sklar, Pamela |
| Předmět: |
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| Zdroj: |
Archives of General Psychiatry; Jan2008, Vol. 65 Issue 1, p53-61, 9p, 1 Chart, 1 Graph |
| Abstrakt: |
The article presents a family-based association study about genes related to lithium mechanism of action and other positional and functional candidate genes in bipolar disorder. A gene-based test of association was used to examine a set of haplotype-tagging single-nucleotide polymorphisms in 379 parent-affected offspring trios. Results of the study show that polymorphisms in major lithium-signaling genes do not seem to contribute to bipolar liability and that further study is necessary for novel candidates and genes previously associated with schizophrenia. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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