Mechanisms for the effect of arginine-containing dermorphin analogue on proliferative processes in the gastric mucosa of albino rats.

Autor: M. Fleishman, E. Zhivotova, V. Deigin, S. Timoshin
Předmět:
Zdroj: Bulletin of Experimental Biology & Medicine; Sep2007, Vol. 144 Issue 3, p309-311, 3p
Abstrakt: Abstract  Treatment with synthetic arginine-containing dermorphin analogue sedatin (100 mg/kg, 5 intraperitoneal injections) stimulated DNA synthesis in the gastric mucosa and decreased spontaneous and induced chemiluminescence in homogenates of the stomach from albino rats. Non-arginine sedatin analogue in the same dose had little effect on DNA synthesis and free radical oxidation. Fivefold treatment with NO synthase inhibitor L-NAME (9.3×10−5 mol/kg) suppressed DNA synthesis in the gastric mucosa. Sedatin did not modulate DNA synthesis against the background of L-NAME administration. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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