| Autor: |
Paolo Palma, Paolo Rossi, Guido Collina, Anna Buccoliero, Bruno Ghiringhello, Maurizio Lestani, Gianlibero Onnis, Daniela Aldovini, Giuseppe Galanti, GianPiero Casadei, Mirella Aldi, Vincenzo Gomes, Pamela Giubilato, Guglielmo Ronco |
| Předmět: |
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| Zdroj: |
American Journal of Clinical Pathology; Jan2008, Vol. 129 Issue 1, p75-80, 6p |
| Abstrakt: |
All cervical intraepithelial neoplasia (CIN) diagnoses identified during the New Technologies for Cervical Cancer trial (ISRCTN81678807) were blindly reviewed by 2 pathologists. Original diagnoses based on colposcopy-guided biopsies were compared with those made by the reviewers who had access to all clinical histologic samples (including postsurgical). Cases downgraded from CIN 2+ by the reviewers were considered indicative of unnecessary treatments. The analyses are presented according to the molecular (high-risk human papillomavirus [HPV]) and/or cytologic diagnosis used to refer the women for colposcopy.We reviewed 812 CIN 1 and 364 CIN 2 + diagnoses. The specificity of colposcopy-guided biopsy was 98% and the sensitivity, 84%. The probability of unnecessary treatment was 27% for women with atypical squamous cells of undetermined significance cytologic findings and 8% for women with low-grade squamous intraepithelial lesion or worse, 10% for HPV+ and positive cytologic findings, and 16% for HPV+ alone. The positive predictive value of the first-level screening test was inversely associated with probability of a histologic false-positive result (P = .015).In screening, a low positive predictive value of the colposcopy-referring test may result in unnecessary treatments. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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