| Autor: |
Cross, Sarah, Soo-Jeong Kim, Weiss, Lauren A., Delahanty, Ryan J., Sutcliffe, James S., Leventhal, Bennett L., Cook Jr., Edwin H., Veenstra-VanderWeele, Jeremy |
| Předmět: |
|
| Zdroj: |
Neuropsychopharmacology; Jan2008, Vol. 33 Issue 2, p353-360, 8p, 5 Charts, 2 Graphs |
| Abstrakt: |
Elevated platelet serotonin (5-hydroxytryptamine, 5-HT) is found in a subset of children with autism and in some of their first-degree relatives. Indices of the platelet serotonin system, including whole blood 5-HT, 5-HT binding affinity for the serotonin transporter (Km), 5-HT uptake (Vmax), and lysergic acid diethylamide (LSD) receptor binding, were previously studied in 24 first-degree relatives of probands with autism, half of whom were selected for elevated whole blood 5-HT levels. All subjects were then genotyped for selected polymorphisms at the SLC6A4, HTR7, HTR2A, ITGB3, and TPH1 loci. Previous studies allowed an a priori prediction of SLC6A4 haplotypes that separated the subjects into three groups that showed significantly different 5-HT binding affinity (Km, p=0.005) and 5-HT uptake rate (Vmax, p=0.046). Genotypes at four individual polymorphisms in SLC6A4 were not associated with platelet 5-HT indices. Haplotypes at SLC6A4 and individual genotypes of polymorphisms at SLC6A4, HTR7, HTR2A, ITGB3, and TPH1 showed no significant association with whole blood 5-HT. Haplotype analysis of two polymorphisms in TPH1 revealed a nominally significant association with whole blood 5-HT (p=0.046). These initial studies of indices of the 5-HT system with several single-nucleotide polymorphisms at loci in this system generate hypotheses for testing in other samples.Neuropsychopharmacology (2008) 33, 353–360; doi:10.1038/sj.npp.1301406; published online 4 April 2007 [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
