Diffusion tensor imaging and chemical shift imaging assessment of heterogeneity in low grade glioma under temozolomide chemotherapy.

Autor:	Sijens, P. E., Heesters, M. A.A.M., Enting, R. H., van der Graaf, W. T.A., Potze, J. H., Irwan, R., Meiners, L. C., Oudkerk, M.
Předmět:	CALCULUS of tensors MAGNETIC resonance GLIOMAS NERVOUS system tumors DRUG therapy ANTINEOPLASTIC agents BRAIN tumors CHOLINE MAGNETIC resonance imaging NUCLEAR magnetic resonance spectroscopy DACARBAZINE THERAPEUTICS
Zdroj:	Cancer Investigation; Dec2007, Vol. 25 Issue 8, p706-710, 5p, 2 Black and White Photographs, 1 Chart, 1 Graph
Abstrakt:	Diffusion tensor imaging and multiple voxel magnetic resonance spectroscopy were performed in the MRI follow-up of a patient with a glioma treated with temozolomide chemotherapy. Tumor shrinkage was paralleled by reductions in choline level and by increases in apparent diffusion coefficient indicating decreased cellularity. Within the tumor, choline level and apparent diffusion coefficient showed a significant inverse correlation (P < 0.01). Fractional anisotropy distribution in the tumor correlated positively with N-acetyl aspartate level (P < 0.001), indicating that these parameters reflect (remaining) axonal structure. Tumor lactate level, also found to decrease under therapy, did not correlate with any other parameter. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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