Thiamine Pyrophosphate Dependent Enzyme Catalyzed Reactions: Stereoselective C-C Bond Formations in Water.

Autor:	Demir, Ayhan S., Ayhan, Peruze, Sopaci, S. Betül
Předmět:	THIAMIN pyrophosphate ENZYMES WATER CHEMICAL bonds CATALYSIS CONDENSATION COENZYMES KETONES CHEMICAL industry PHARMACEUTICAL industry
Zdroj:	CLEAN: Soil, Air, Water; Nov2007, Vol. 35 Issue 5, p406-412, 7p, 13 Diagrams
Abstrakt:	The article evaluates recent advances in enzyme catalyzed stereoselective C-C bond formations in water with the use of thiamine pyrophosphate (TPP) dependent enzymes. These enzymes, which are capable of acyloin-type condensation reactions in water under mild conditions, include acetohydroxyacid synthase, benzaldehyde lyase, benzonylformate decarboxylase, pyruvate decarboxylase, and phenylpyruvate decarboxylase. These TPP-dependent enzynmes lead to chiral alpha-hydroxy ketones, which are the building blocks for the pharmaceutical and chemical industries.
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text