| Autor: |
Ryszard Grenda, Elke Wühl, Mieczyslaw Litwin, Roman Janas, Joanna Sladowska, Klaus Arbeiter, Ulla Berg, Alberto Caldas-Afonso, Michel Fischbach, Otto Mehls, Peter Sallay, Franz Schaefer, for the ESCAPE Trial group |
| Předmět: |
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| Zdroj: |
Nephrology Dialysis Transplantation; Dec2007, Vol. 22 Issue 12, p3487-3487, 1p |
| Abstrakt: |
The severity and dynamics of renal tissue damage in chronic kidney disease (CKD) may be reflected by the urinary excretion of vasoactive and growth factors released by the damaged kidney. Urinary excretion of ET-1, TGF-β1 and VEGF165 was evaluated in 303 children with CKD stage II–IV (GFR 48 ± 22 ml/min/1.73 m2) and 81 age-matched healthy controls. Major renal disease groups were hypo-/dysplastic kidney disease (N = 183), obstructive uropathies (N = 47), glomerulopathies (N = 34), nephronophthisis (N = 19) and polycystic kidney disease (N = 20). Results. The mean urinary excretion rates of each of the three putative biomarkers were significantly elevated in CKD patients compared to controls: 965 ± 2042 vs 216 ± 335 fmol/g creatinine for ET-1; 252 ± 338 vs 155 ± 158 ng/g for VEGF; 31.6 ± 37.0 vs 10.9 ± 9.8 ng/g for TGF-β1 (each P r = –0.22, −0.32 and −0.17, all P r = –0.21, –0.13 and –0.15; P Conclusions. Children with CKD exhibit significantly elevated urinary excretion of ET-1, TGF-β1 and VEGF165 in comparison to healthy children. Urinary excretion of these biomarkers was most enhanced in patients with obstructive uropathies. A positive correlation between urinary TGF-β1 and VEGF165 excretion, shown both in patients and healthy controls, indicates an interdependent nature of their generation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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