Possible Triggers and Mode of Onset of Chronic Fatigue Syndrome.

Autor: De Becker, P., McGregor, N., Meirleir, K. De
Předmět:
Zdroj: Journal of Chronic Fatigue Syndrome; 2002, Vol. 10 Issue 2, p3-18, 16p, 3 Charts
Abstrakt: To identify the possible triggering events of CFS, we collected data on 1546 CFS patients and 309 excluded fatigued patients. Using extensive present and past medical history and lab reports as close as possible to the date of onset, an attempt was made to identify the agents that could play a role in the disease process. Significant differences were found between the events at onset, between the Fukuda or Holmes definitions and a sudden as distinct from a gradual onset. We further found a series of subgroups of events that occurred at onset of CFS. Each of these onset event clusters was associated with an infectious event, blood transfusion or hepatitis B vaccination. In a large percentage of our study group an infectious event was combined with a non-infectious event. In summary, we can conclude that a number of different stressors and consequent immunological and neuroendocrinological changes can contribute to the onset of CFS. [ABSTRACT FROM PUBLISHER]
Databáze: Complementary Index