| Autor: |
Dicker, Jürgen W., Fransen, Justin H., Van Bavel, Casandra C., Briand, Jean-Paul, Jacobs, Cor W., Muller, Sylviane, Berden, Jo H., Van der Vlag, Johan |
| Předmět: |
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| Zdroj: |
Arthritis & Rheumatism; Jun2007, Vol. 56 Issue 6, p1921-1933, 13p, 1 Chart, 5 Graphs |
| Abstrakt: |
The article focuses on a study which evaluated whether apoptosis-induced histone modifications are targets for immune system in systemic lupus erythematosus (SLE). The epitope of the monoclonal antihistone autoantibody KM-2, which is derived from a lupus mouse, was mapped by random peptide phage display. The apoptosis-induced acetylation of histone H4 (H4) at lysines 8, 12, and 16 was recognized KM-2. It concluded that apoptosis-induced acetylation of nucleosomes may represent an important driving force in the development of lupus. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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