Discontinuation of chemoprophylaxis against Pneumocystis carinii pneumonia in patients with HIV infection. HIV Outpatient Study (HOPS) Investigators.

Autor:	Yangco, Bienvenido G., Von Bargen, Jennifer C., Yangco, B G, Von Bargen, J C, Moorman, A C, Holmberg, S D
Předmět:	PNEUMOCYSTIS pneumonia HIV-positive persons THERAPEUTIC use of protease inhibitors ANTIFUNGAL agents ANTI-HIV agents CHEMOPREVENTION COMBINATION drug therapy COMPARATIVE studies HIV infections LONGITUDINAL method RESEARCH methodology MEDICAL cooperation RESEARCH AIDS-related opportunistic infections VIRAL load EVALUATION research CD4 lymphocyte count
Zdroj:	Annals of Internal Medicine; 02/01/2000, Vol. 132 Issue 3, p201-205, 5p, 2 Charts
Abstrakt:	Background: HIV-infected patients with sustained immunologic improvement from antiretroviral therapy may be able to discontinue chemoprophylaxis against Pneumocystis carinii pneumonia (PCP).Objective: To compare PCP incidence in HIV-infected patients who had sustained CD4+ lymphocyte counts greater than 200 cells/mm3 and who either discontinued or continued PCP prophylaxis.Design: Nonrandomized prospective cohort study.Setting: 10 HIV clinics in eight U.S. cities.Patients: 146 patients had follow-up visits for a mean of 18.2 months after discontinuation of PCP prophylaxis, and 345 patients who continued PCP prophylaxis had follow-up visits for a mean of 14.0 months.Measurements: Incidence of PCP.Results: Patients who discontinued PCP prophylaxis had higher maximum and minimum CD4+ cell counts and lower vira loads than patients who continued PCP prophylaxis. Pneumocystis carinii pneumonia did not develop in either group (upper 95% exact binomial confidence limit of incidence for those who discontinued PCP prophylaxis, 2.3/100 person-years).Conclusions: Discontinuation of PCP chemoprophylaxis may be appropriate for some HIV-infected ambulatory patients. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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