Effect of systemic treatment with antibodies against glutamate on the seizure response of C57Bl/6 mice after pentylenetetrazole kindling.

Autor: M. Karpova, L. Vetrile, L. Kuznetsova, N. Klishina, N. Trekova
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Zdroj: Bulletin of Experimental Biology & Medicine; Jun2007, Vol. 143 Issue 6, p670-672, 3p
Abstrakt: Abstract  We studied the effect of single intraperitoneal injection of antibodies against glutamate on acute generalized epileptiform activity induced by intravenous injection of pentylenetetrazole in kindled C57Bl/6 mice. We found that in animals at various stages of kindling, administration of antibodies against glutamate in a dose of 25 mg/kg 1.5 h before testing increases the threshold of clonic seizures and tonic phase of seizures with lethal outcome and latency of seizure development, i.e. produces an antiepileptic effect. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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