Effect of β-adrenoceptor blockers on growth of neurites in spinal ganglia in organotypic tissue culture.

Autor: V. Penniyainen, E. Lopatina, V. Tsyrlin
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Zdroj: Bulletin of Experimental Biology & Medicine; May2007, Vol. 143 Issue 5, p556-558, 3p
Abstrakt: Abstract  We studied the effects of norepinephrine and β1-adrenoblockers atenolol and metoprolol on the growth of neuritis in organotypic tissue culture of spinal ganglia from 10–12-day chicken embryos. Atenolol (10−4 M) accelerated the growth of neurites in spinal ganglia by 45%, while metoprolol inhibited the growth of the explants almost in all examined concentrations (10−10–10−4 M). Thus, β1-adrenoblockers can produce opposite effects on neurite growth. Both atenolol and metoprolol abolished the neurite-stimulating effect of norepinephrine, probably, because this effect is mediated via β1-adrenoreceptors of spinal ganglia. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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