| Autor: |
Colman, Ricki J., Ramsey, Jon J., Colman, R J, Ramsey, J J, Roecker, E B, Havighurst, T, Hudson, J C, Kemnitz, J W |
| Předmět: |
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| Zdroj: |
Journals of Gerontology Series A: Biological Sciences & Medical Sciences; Jul99, Vol. 54 Issue 7, pB283-B290, 8p, 2 Charts, 10 Graphs |
| Abstrakt: |
Dietary restriction (DR) is the only intervention that has been shown to increase average and median life span in laboratory rodents. The effect of long-term, moderate DR on body composition and fat distribution was evaluated in male rhesus monkeys. Thirty animals (8-14 years of age)fed either 30% less than baseline intake (R, n = 15) or allowed to eat to satiety (C, n = 15), have been assessed semiannually using somatometrics and dual-energy alpha-ray absorptiometry (DXA)for 7.5 years. R subjects have reduced body weight (p <.0001), total body fat (p < .0001), and percentage body fat located in the abdominal region (p < .05). In addition, there has been a sustained reduction in plasma leptin concentrations (p <.001). These findings suggest reduced risk for common morbidities, such as insulin resistance, dyslipidemia, and type 2 diabetes mellitus, that are associated with advancing age and increased levels of bodyfat, especially in the visceral depot. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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