The bioinorganic and medicinal chemistry of carboranes: from new drug discovery to molecular imaging and therapy.

Autor: Armstrong, Andrea F., Valliant, John F.
Předmět:
Zdroj: Dalton Transactions: An International Journal of Inorganic Chemistry; Sep2007, Vol. 2007 Issue 38, p4240-4251, 12p, 2 Color Photographs, 16 Diagrams, 1 Graph
Abstrakt: The role of carboranes in medicinal chemistry has diversified in recent years and now extends into areas of drug discovery, molecular imaging, and targeted radionuclide therapy. An introduction to carborane chemistry is provided to familiarize the non-expert with some key properties of these molecules, followed by an overview of current medicinally-orientated research involving carboranes. The broad-ranging nature of this research is illustrated, with emphasis placed on recent highlights and advances in this field. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index