| Autor: |
W&3x00F8;jdemann, K. R., Shalmi, A. C., Christiansen, M., Larsen, S. O., Sundberg, K., Brocks, V., Bang, J., N∅rgaard-Pedersen, B., Tabor, A., Wøjdemann, K R, Nørgaard-Pedersen, B |
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| Zdroj: |
Ultrasound in Obstetrics & Gynecology; Mar2005, Vol. 25 Issue 3, p227-233, 7p, 2 Diagrams, 5 Charts, 1 Graph |
| Abstrakt: |
Objective: To determine the performance of screening for Down syndrome (DS) and other major chromosomal abnormalities using nuchal translucency (NT), free beta-human chorionic gonadotropin (beta-hCG) and pregnancy-associated plasma protein-A (PAPP-A) in a prospective study of a non-selected population. Methods: Of 9941 women with an early ultrasound examination, NT was measured in 8622 singleton pregnancies with a gestational age between 10 + 3 and 13 + 6 weeks. beta-hCG and PAPP-A were analyzed in 6441 cases. Detection rates (DR) and false-positive rates (FPR) for the NT screening, the double test (beta-hCG and PAPP-A) and the combined test (NT and the double test) were calculated using a 1 : 250 cut-off. Results: NT could be measured in 97.5% of cases. The DR for DS with NT screening alone was 75% with a FPR of only 1.8%. The double test detected 73% and the combined test 91%, for FPRs of 8.8% and 2.1%, respectively. We detected 80% of fetuses with other major chromosomal abnormalities with a combination of NT screening and other ultrasound findings. Low beta-hCG and PAPP-A values (below 0.4 MoM) were observed in 0.5% of the women including all cases of triploidy and trisomy 18 and 13. Conclusions: The performance of a screening strategy for DS using a combination of NT and the double test was superior to that using either NT or the double test alone due to a very low FPR and a higher DR. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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