Development of drug resistance in the population of colon cancer cells under the effect of multifunctional protein YB-1.

Autor:	A. Vaiman, T. Stromskaya, E. Rybalkina, A. Sorokin, L. Ovchinnikov, A. Stavrovskaya
Předmět:	CELL nuclei ORGANELLES ANUCLEATE cells CHROMOSOMES
Zdroj:	Bulletin of Experimental Biology & Medicine; Apr2007, Vol. 143 Issue 4, p463-466, 4p
Abstrakt:	Abstract  The effects of YB-1 gene on the expression level of P-glycoprotein and drug resistance of tumor cells were studied in cultured HCT116 colon cancer cells. Transitory transfection of chimeric YB-1/GFP gene rendered HCT116 cells a selective advantage in a medium with vinblastine, which caused translocation of the chimeric protein into cell nuclei. This was paralleled by an increase in the expression of P-glycoprotein (multiple drug resistance protein). [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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