Role of Trypanosoma cruzi Autoreactive T Cells in the Generation of Cardiac Pathology.

Autor:	GIRONÈS, NÚRIA, CARRASCO‐MARIN, EUGENIO, CUERVO, HENAR, GUERRERO, NÉSTOR ADRIÁN, SANOJA, CRISTINA, JOHN, SPARROW, FLORES‐HERRÁEZ, REYES, FERNÁNDEZ‐PRIETO, LORENA, CHICO‐CALERO, ISABEL, SALGADO, HUGO, CARRIÓN, JAVIER, FRESNO, MANUEL
Předmět:	CHAGAS' disease TRYPANOSOMIASIS TRYPANOSOMA cruzi DISEASE complications CARDIOMYOPATHIES T cells AUTOIMMUNITY PATHOLOGY ETIOLOGY of diseases
Zdroj:	Annals of the New York Academy of Sciences; 2007, Vol. 1107, p434-444, 11p, 1 Chart, 1 Graph
Abstrakt:	Chagas disease, caused by Trypanosoma cruzi, affects several million people in Central and South America. About 30% of chronic patients develop cardiomyopathy probably caused by parasite persistence and/or autoimmunity. While several cross-reactive antibodies generated during mammal T. cruzi infection have been described, very few cross-reactive T cells have been identified. We performed adoptive transfer experiments of T cells isolated from chronically infected mice. The results showed the generation of cardiac pathology in the absence of parasites. We also transferred cross-reactive SAPA-specific T cells and observed unspecific alterations in heart repolarization, cardiac inflammatory infiltration, and tissue damage. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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