Changes in urinary dinor dihydro F2-isoprostane metabolite concentrations, a marker of oxidative stress, during and following asthma exacerbations.

Autor: Wu, Pingsheng, Roberts Ii, Lyman J., Shintani, Ayumi K., Sheller, James R., Minton, Patricia A., Higgins, Stanley B., Hartert, Tina V.
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Zdroj: Free Radical Research; Sep2007, Vol. 41 Issue 9, p956-962, 7p, 1 Chart, 2 Graphs
Abstrakt: To investigate changes in oxidant stress during and following acute asthma exacerbations, this stidy measured 2,3-dinor-5,6-dihydro-15-F2t-IsoP (F2-IsoP-M), the major urinary metabolite of 15-F2t-IsoP, in eight asthmatic adults, during and following an asthma hospitalization. F2-IsoP-M concentrations at admission and follow-up were significantly higher than discharge (admission median: 4.12 ng/Cr mg, range 1.89-7.8; follow-up: 2.47 ng/Cr mg (1.56-6.86); discharge: 1.42 ng/Cr mg (0.7-4.44); both p<0.01), but not significantly different between admission and follow-up. F2-IsoP-M concentrations at follow-up were higher than a control group with stable asthma (0.68 ng/Cr mg (0.31-1.5), p=0.0008). In conclusion, asthma exacerbations requiring hospitalization are associated with 6-fold higher urinary F2-IsoP-M concentrations compared to stable asthmatics. F2-IsoP-M concentrations decreased significantly during hospitalization, but significant elevations 3 months following hospitalization suggest ongoing oxidative stress despite clinical improvement. Urinary F2-IsoP-M may be a clinically useful, simple non-invasive systemic measure of oxidative stress in asthmatics, providing information not captured by spirometry or symptoms. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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