Apoptosis in Prostate Carcinoma before and after Neoadjuvant Therapy with LH-RH Analog.

Autor:	BENCINI, STEFANIA, MIGALDI, MARIO, CASTAGNETTI, GIOVANNI, PINCELLI, CARLO, FERRARI, PAOLO, GAETANI, CARMELA, TRENTINI, GIAN PAOLO
Předmět:	CANCER treatment PROSTATE cancer APOPTOSIS MALE reproductive organs CELL death THERAPEUTICS TUMORS CYSTS (Pathology) CANCER
Zdroj:	Annals of the New York Academy of Sciences; 2004, Vol. 1010 Issue 1, p789-792, 4p
Abstrakt:	This study investigated apoptosis in prostate cancer before and after neoadjuvant treatment with LH-RH analog, demonstrating that this therapy induced high AI and bax and survivin overexpression, thus acting as a pro- apoptotic agent in prostate cancer. A statistically significant correlation was found between high AI and overexpression of bax protein after therapy. It is probable that this kind of therapy is deeply implicated in promoting the apoptotic intrinsic pathway. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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