Factors Influencing Treatment Efficacy of 24-Week Combination Therapy with Interferon α-2b Plus Ribavirin for Chronic Hepatitis C.

Autor: Mitsuhiko Moriyama, Hiroshi Matsumura, Kazushige Nirei, Yasuo Arakawa, Hiroaki Yamagami, Masahiro Ogawa, Miki Kaneko, Shuichi Matsuoka, Shuichi Amaki, Naohide Tanaka, Yasuyuki Arakawa
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Zdroj: Digestive Diseases & Sciences; Sep2007, Vol. 52 Issue 9, p2418-2426, 9p
Abstrakt: Abstract  The efficacy of a combination therapy of interferon (IFN) α-2b plus ribavirin (RBV) in chronic hepatitis C, and the factors contributing to efficacy, were investigated. One hundred eighty-six cases were enrolled in this study and treated with a combination of IFN α-2b plus RBV. IFN α-2b was administered at 6–10 mega-units daily for 2–4 weeks and three times per week for 20–22 weeks, in combination with oral intake of RBV at 600 or 800 mg for 24 weeks. Rates of sustained virological response (SVR) were 34.9% in serogroup 1 (SG1) and 82.5% in SG2. SVR rates in cases with both drugs discontinued, reduced, and unchanged were 4.2%, 40%, and 42.7% in SG1 and 42.9%, 76.9%, and 91.9%, in SG2. In terms of the total RBV dose per kilogram body weight, SVR rates were 14.3% and 46.2% with [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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