| Autor: |
Kodadi, Mohamed El, Benamar, Malika, Ibrahim, Bouabdallah, Zyad, Abdelmajid, Malek, Fouad, Touzani, Rachid, Ramdani, Abdelkrim, Melhaoui, Ahmed |
| Zdroj: |
Natural Product Research; Sep2007, Vol. 21 Issue 11, p947-952, 6p, 1 Diagram, 2 Graphs |
| Abstrakt: |
Two new tripodal compounds - 4-{bis[(3,5-dimethyl-1H-pyrazole-1-yl)methyl]amino}butane-1-ol (1); ethyl 1-[((2-hydroxyethyl){[3-(ethoxycarbonyl)-5-methyl-1H-pyrazole-1-yl]methyl} amino)methyl]-5-methyl-1H-pyrazole-3-carboxylate (2) were reported. The evaluation of the cytotoxic properties in vitro of these ligands, was examined on two tumor cell lines - P815 (mastocytome murine) and Hep (carcinoma of human larynx). The concentration required to induce 50% of lysis (IC50) was more pronounced against P815 cell line (IC50: 39.42 µg mL-1 for the compound 1 and 97.74 µg mL-1 for the compound 2) than the Hep cell line (IC50: 83.49 µg mL-1 for compound 1 and 185.30 µg mL-1 for compound 2). Statistical analysis shows that the compound 1 is two to three folds more cytotoxic than the compound 2 (p < 0.05). Interestingly, the cytotoxic activity depends strongly on both the substituents linked to the aminic nitrogen and pyrazolic rings. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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