Synthesis of some 4-arylidenamino-4H-1,2,4-triazole-3-thiols and their antituberculosis activity.

Autor:	Özdemir, Ahmet, Turan-Zitouni, Gulhan, Asim Kaplancikli, Zafer, Chevallet, Pierre
Předmět:	DRUG resistance MYCOBACTERIAL diseases PATHOGENIC microorganisms MICROBIOLOGY TRIAZOLES ALDEHYDES
Zdroj:	Journal of Enzyme Inhibition & Medicinal Chemistry; Aug2007, Vol. 22 Issue 4, p511-516, 6p, 1 Diagram, 2 Charts
Abstrakt:	The increasing clinical importance of drug-resistant mycobacterial pathogens has lent additional urgency to microbiological research and new antimycobacterial compound development. For this purpose, new triazoles were synthesized and evaluated for antituberculosis activity. A series of 4-arylidenamino-4H-1,2,4-triazole-3-thiol derivatives (2a-n) were synthesized from the treatment of 4-amino-4H-1,2,4-triazoles-3-thiol (1) with the respective aldehydes and were evaluated for antituberculosis activity against Mycobacterium tuberculosis H37Rv (ATCC 27294), using the BACTEC 460 radiometric system and BACTEC 12B medium. Compound 2k showed an intereting activity at 6.25 μg/mL with a 87 percentage inhibition. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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