| Autor: |
Shimajiri, Yoshinori, Furuta, Machi, Kadoya, Yoshiki, Yamada, Shoichi, Sanke, Tokio |
| Předmět: |
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| Zdroj: |
Diabetes; Jun2007 Supplement 1, Vol. 56, pA606-A606, 1/4p |
| Abstrakt: |
RFD [estimated GFR (eGFR) <60ml/min/1.72m²] is a major factor of Chronic Kidney Disease, which is one of the independent risk factor for the cardiovascular disease (CVD). Thus, RFD has been now highlighted for preventing the severe outcome, such as CVD, peripheral arterial disease (PAD) in addition to hemodialysis. Recent study shows that RFD does not always have proteinuria. Our aim in this study is to identify the frequency of the RFD in the absence of macroalbuminuria in Japanese T2DM and to understand clinical features of the RFD. We calculated the eGFR using MDRD Study equation, and multiplied an ethnical coefficient (0.881) to adjust for the Japanese. The macroalbuminuria was evaluated by the urinary albumin to creatinine (Cr) ratio equal or more than 300mg/gCr. The percentage of RFD in 936 T2DM patients was 34.8% (326/936). When the patients were limited only with diabetic retinopathy (RFD related diabetic nephropathy), the percentage was 17.6% (165/936). Of the T2DM complicated with RFD, the frequency of patients in the absence of macroalbuminuria was 50.6% (165/326) and that limited with diabetic retinopathy was 40.0% (66/165). In the T2DM patients in the absence of macroalbuminuira, the duration-matched comparison between those with and without RFD demonstrated that the frequency of CVD (20.4% Vs 7.7%, P=0.012) was significantly high in the patients with RFD and that of PAD determined by ankle-brachial index less than 0.9 (15.6% Vs 5.7%, P=0.07) was higher trend in RFD patients. We clarified that the frequency of RFD related diabetic nephropathy and high percentage of RFD in the absence of macroalbuminuria in Japanese T2DM. We also demonstrated that low GFR in the absence of macroalbuminuia increase the macroangiopathy. Given these results, we recommend evaluating the GFR from the early phase of diabetes (even in the absence of albuminuria) as an interventional target. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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