| Autor: |
Sagawa, Chigako, Okamoto, Mayumi, Taki, Masahumi, Ota, Rei, Egashira, Fujiko, Kasuga, Kouichi, Kawamura, Wataru, Ogihara, Norikazu, Hayashi, Youichi, Nakagawara, Hiroshi, Ogawa, Masahiro, Arakawa, Yasuyuki, Ito, Itsuo, Komoriya, Tomoe, Kohno, Hideki |
| Předmět: |
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| Zdroj: |
Diabetes; Jun2007 Supplement 1, Vol. 56, pA588-A588, 1/4p |
| Abstrakt: |
Chronic inflammation is known to play a role in arteriosclerosis. High-sensitivity C-reactive protein (hsCRP), a marker of inflammation, has attracted attention as a marker for the presence and progression of arteriosclerosis, hsCRP concentration has been shown to be significantly associated with BMI, and immunoreactive insulin (IRI) and HDL cholesterol levels, although there is limited information on the usefulness of this inflammation marker in patients with diabetes(DM). In a previous report, we described a novel assay for super-hsCRP(shsCRP), which is more sensitive than conventional hsCRP assays. In the present study, we assessed the clinical utility of this technique for DM patients. We first developed a latex reagent that contained amino acids spacer in order to achieve a high-sensitivity assay. Of the amino acids used, a glycine spacer, which had particularly high reactivity, was found to be most appropriate for measuring shsCRP levels. The study population included 87 outpatients with type 2 DM, without diabetic nephropathy of stage III or higher, and with no documented history of cardiovascular disease. The mean age of the patients was 61 years, and the mean HbA1c value was 7.4%. We examined the relationship between super-hsCRP concentration and the following factors: BMI; blood pressure; fasting blood glucose; HbA1c; homeostasis model assessment of insulin resistance (HOMA-R); IRI; total cholesterol; LDL cholesterol; HDLI; triglyceride; smoking; use of antihyperlipidemic, antihypertensive or antiplatelet agents; pulse wave velocity; and maximum thickness of the intima-media complex (maxIMC). The highest and lowest shsCRP concentrations were 1528.8 ng/ml and 113.5 ng/ml, respectively, with a mean of 592.1 ng/ml. ShsCRP concentrations were positively correlated with BMI, fasting blood glucose, HOMA-R, and maxIMC, but were negatively correlated with HDL. Having a large number of metabolic syndrome risk factors was also associated with a higher shsCRP concentration. We found that in patients with type 2 DM shsCRP concentration was associated with maxIMC, in addition to obesity, insulin resistance, and abnormal lipid metabolism, which are risk factors for metabolic syndrome. These results suggest that shsCRP might be clinically useful as a marker for arteriosclerotic disease. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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