| Autor: |
Rodacki, Melanie, Dantas, Joana, Nabuco, Aline, Barone, Bianca, Mac Dowell, Renata, Bravo, Michelle, Perricelli, Paula, Brum, Julia, Ornellas, Phelipe, Belem, Luciana, Oliveira, Marcus M., Szundy, Renata, Luescher, Jorge, Kupfer, Rosane, Vangelotti, Andrea M., Zajdenverg, Lenita, Milech, Adolpho, Oliveira, José E. |
| Předmět: |
|
| Zdroj: |
Diabetes; Jun2007 Supplement 1, Vol. 56, pA240-A241, 2p |
| Abstrakt: |
The aim of this study was to detect the frequency of diabetic ketoacidosis (DKA) at the onset of type 1 diabetes (T1D) in a multi-ethnic population from Brazil and possible interfering factors. We have retrospectively analyzed the medical records of 545 patients with T1D from two of the main local diabetes treatment centers. For statistical analysis, Chi Square and Mann Whitney U tests were used to compare nominal and ordinal data between groups. The study population comprised 296 women and 249 men, 312 white and 233 non-white individuals. Their mean T1D duration was 10.1 ± 7.8 years and their mean age at onset was 11.9 ± 7.9 y/o. The age at onset distribution was categorized as 0-5, 6-10, 11-15, 16-20 and and >20 y/o. DKA occurred in 179 patients (32.8%) at the diagnosis. No difference was found in the DKA frequency according to gender (p=0.78). The complication was more common in patients diagnosed ≤ 5 years of age than others (44.7 vs 30%; p=0.005). Patients with DKA were significantly younger than those without the complication (10.2 ±7.2 vs 12.8 ± 8.1 y/o; p<0.001).The frequency of DKA at onset of T1D was higher in non-white than white individuals (42.9% vs 25.4%; p<0.0001). Although the mean age at diagnosis of T1D was lower in non-white patients than white ones (10.74 ± 6.94 y/o vs 12.91 ± 8.41 y/o; p=0.005), multivariate analysis indicated that ethnicity is independently associated with DKA at onset (p=0.01). The prevalence of DKA at the diagnosis of T1D did not change in the past decades (31.8%, 30.4%, 28% and 38.8% in 60s + 70s, 80s, 90s and 00s), except for a significantly higher prevalence in patients diagnosed since 2000 when compared to those diagnosed in the 90s (28% vs 38.8%; p=0.019). The age at onset of T1D did not differ significantly between those two decades (p=0.37). To conclude, a significant proportion of individuals present DKA at the onset of T1D in this population, especially very young children and non-white individuals. The predominance of DKA in non-white individuals might be related to socio-economic factors, low suspicious of the disease in this group or to a peculiarity of T1D in this population. Unfortunately, the frequency of DKA has not declined in the past decades. Educational programs for detection of early signs of the disease might help to change this scenarium. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
