| Autor: |
Lutgers, Helen L., Gerrits, Esther G., Bilo, Henk J., Smit, Andries J. |
| Předmět: |
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| Zdroj: |
Diabetes; Jun2007 Supplement 1, Vol. 56, pA173-A174, 2p, 1 Graph |
| Abstrakt: |
Increased formation and accumulation of advanced glycation endproducts (AGEs) is one of the pathogenetic mechanisms of accelerated atherosclerosis in Type 2 diabetes (T2DM). Some AGEs have characteristic fluorescent properties, which can be non-invasively measured as skin autofluorescence (AF). We have previously demonstrated the relation between skin AF and chronic diabetes complications. This study aims to assess whether skin AF is additive to classical risk factors combined in the UKPDS risk-engine in predicting cardiovascular disease. In 2001, 973 primary care T2DM-patients were included (mean age 66 yrs, mean HbA1c 7.0% and mean diabetes duration of 6.3 yrs). Skin AF, using a prototype of the current AGE reader, and UKPDS risk scores were assessed at baseline. The UKPDS risk-engine, downloaded from the UKPDS website, was used. Follow-up ended at January 2005. Primary endpoint was mortality or non-fatal cardiovascular event (coronary heart disease, cerebrovascular accidents, peripheral vascular disease). Patients were categorized in four groups (Figure). During a follow-up of about 3.5 years, 6 patients were lost to follow-up. In the remaining 967 patients, there were 161 events. Kaplan-Meier survival curves (Figure) showed significant differences between the groups, except between group 2 and 3 (p<0.05). Autofluorescence has an additional value to the UKPDS risk-score in the risk assessment of the occurrence of cardiovascular complications. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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