| Autor: |
Engels, Eric A., Atkinson, Jonnae O., Graubard, Barry I., McQuillan, Geraldine M., Gamache, Christine, Mbisa, Georgina, Cohn, Silvia, Whitby, Denise, Goedert, James J. |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 7/15/2007, Vol. 196 Issue 2, p199-207, 9p |
| Abstrakt: |
Background. Human herpesvirus 8 (HHV-8) causes Kaposi sarcoma. In the United States, transmission routes for HHV-8 are uncertain. Methods. The National Health and Nutrition Examination Survey III sampled individuals from the US general population (1988-1994). We used enzyme immunoassays (EIAs) to measure HHV-8 antibodies (K8.1 and open reading frame [ORF] 73 antigens) in 13,894 surveyed adults. HHV-8 seroprevalence was examined according to sexual history and viral coinfection markers. Results. Overall, seroprevalence was low when a highly specific cutoff was used (K8.1, 1.6%; ORF73, 1.5%) but was higher when a less-specific cutoff was used (K8.1, 7.1%; ORF73, 7.4%). When the more-specific approach was used, K8.1 seroprevalence was similar in men and women. Men who have sex with men (MSM) had a higher K8.1 seroprevalence (8.2%). Among other men, K8.1 seroprevalence was marginally associated with duration of heterosexual activity (P = .1) and was positively associated with the lifetime number of sex partners (P = .04) and with coinfections with hepatitis B virus (6.1% vs. 1.2% without coinfection; P < .001) and herpes simplex virus 2 (2.7% vs. 1.0%; P = .1). Among women, K8.1 seroprevalence was not significantly related to duration of sexual activity, the lifetime number of sex partners, or viral coinfections. The ORF73 EIA revealed similar but less clear-cut patterns. Conclusions. Among men, HHV-8 transmission may occur through sexual activity, particularly sex with other men. No evidence was observed for heterosexual transmission to women. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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