CIGARETTE SMOKE-INDUCED HYPERCAPNIC EMPHYSEMA IN C3H MICE IS ASSOCIATED WITH INCREASES OF MACROPHAGE METALLOELASTASE AND SUBSTANCE P IN THE LUNGS.

Autor:	Xu, J., Xu, F., Wang, R., Seagrave, JC., Lin, Y., March, T. H.
Předmět:	PULMONARY emphysema HYPERCAPNIA HYPOXEMIA INFLAMMATION SUBSTANCE P CIGARETTE smoke
Zdroj:	Experimental Lung Research; Jun/Jul2007, Vol. 33 Issue 5, p197-215, 19p, 1 Diagram, 1 Chart, 5 Graphs
Abstrakt:	The authors tested whether macrophage metalloelastase (MMP-12) and substance P (SP) were increased in the cigarette smoke (CS)-exposed female C3H/HeN mice with hypercapnic emphysema. The authors found that as compared to control (filtered air), 16 weeks of CS exposure significantly up-regulated mRNA and protein levels of MMP-12, the ratio of MMP-12/tissue inhibitor of matrix metalloproteinase-1, and SP/preprotachykinin-A (a precursor to SP) in the lungs. Importantly, a significant correlation was found between MMP-12 and SP, and between MMP-12/SP and the degrees of hypoxemia/hypercapnia denoted in CS-exposed mice. These data suggest a possible involvement of SP and MMP-12 in the pathogenesis of severe COPD. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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