| Autor: |
Ooi, Lezanne, Bingham, Andrew J., Wood, Ian C. |
| Předmět: |
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| Zdroj: |
FASEB Journal; Apr2007, Vol. 21 Issue 5, pA654-A655, 2p |
| Abstrakt: |
The most common disorder causing sudden cardiac death in young people is the cardiac disease, hypertrophic cardiomyopathy (HCM). HCM is characterised by cardiac hypertrophy (an abnormal thickening of the heart muscle) and high levels of brain and atrial natriuretic peptides (BNP and ANP). REST is an important transcriptional repressor of ANP and BNP expression and lower levels of REST in hypertrophic, compared to normal hearts, may contribute to the disease phenotype. The aim of this study was to investigate the molecular mechanisms of REST-mediated repression and its potential role in the control of hypertrophy. Inhibition of REST function resulted in an increase in ANP and BNP gene expression that correlated with increases in histone acetylation and dimethylation of H3 lysine 4 at the ANP and BNP promoters. Additionally, increasing REST expression in adult cardiomyocytes prevented increases in ANP and BNP expression by the hypertrophic agonist, endothelin-1. This data provides evidence that a therapeutic strategy aimed at augmenting REST and/or the action of its corepressors may be effective in treating cardiac hypertrophy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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