| Autor: |
Soo Jung Kim, Eun Hye Chae, Hwayoung Lee, Ji-Myung Kim, Seung Ju Roh, Nam Soo Chang |
| Předmět: |
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| Zdroj: |
FASEB Journal; Apr2007, Vol. 21 Issue 5, pA345-A345, 1/5p |
| Abstrakt: |
We hypothesized that maternal folic acid nutrition status might affect the Synthesis of cerebral MBP in the offspring. Female rats were fed either folic acid sufficient or deficient (8 or 0mg/kg diet) diet from 2 wks prior to the mating till the entire pregnancy and lactation. After weaning, the offspring of folic acid deficient group were divided into 2 groups and were fed either folic acid sufficient or folic acid deficient diet for 4 weeks. The maternal folic acid deficiency caused a significant decrease in plasma folate and hepatic SAM/SAH ratio with a concomitant increase in plasma homocysteine in their, offspring. Folic acid supplementation during the weaning period made plasma folate and homocysteine level, and hepatic SAM/SAH ratio comparable to those who were maintained on a folic acid sufficient diet throughout the entire experimental period. Compared to the folic acid sufficient group, maternal folic acid deficiency caused a significant decrease in the expression of MBP in the spinal cord. Folic acid supplementation during the weaning period failed to cause an increase in the expression of MBP in the spinal cord. These results suggested that maternal folic acid status may affect the synthesis of MBP and thus influence the development of myelin in their offspring. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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