| Abstrakt: |
Investigating the role of appetite-related hormones on energy balance and body composition when varying diets are consumed could provide insight into the etiology of obesity. Eight male subjects, ages 20-30, were used in this study: four normal subjects with BMI of 19-24 and four overweight/obese subjects with of BMI of 27-30. Each subject received both treatments by a crossover design. Two normal and two overweight subjects were assigned to the Atkins' diet. The Atkins' diet contained 10% of energy as carbohydrate, 45% of energy as protein, and 45% of energy as lipid. The remaining two normal and two overweight subjects were assigned to the AHA diet that contained 63% of energy as carbohydrate, 12% of energy as protein, and 25% of energy as lipid. Each diet was fed for 14 days, and then subjects switched to the other diet. On days 6 and 20, breakfast was consumed before 8 am and blood was taken at one hour before and after the noon meal. On days 14 and 28, subjects were fasted and blood samples were taken at 11 am and one hour after the noon meal. Plasma samples were analyzed for active and total ghrelin, leptin, insulin, glucagon, growth hormone, and adiponectin. Hormone concentrations responded differently to diet, BMI, day, period, and interactions of these variables. These results indicate a relationship of appetite-related hormones wit [ABSTRACT FROM AUTHOR] |
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