| Autor: |
Hyde, Dallas M., Tyler, Nancy K., Putney, Lei F., Janssen, William J., Henson, Peter M., DeHoff, Robert T. |
| Předmět: |
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| Zdroj: |
FASEB Journal; Apr2007, Vol. 21 Issue 5, pA8-A8, 1/4p |
| Abstrakt: |
Emphysema, a chronic obstructive lung disease, is characterized by loss of elasticity of the lung tissue and destruction of interalveolar septa that results in small airways collapse during expiration. Design-based methods that count alveolar opening rings to estimate alveolar number are difficult in emphysematous lungs because portions of the alveolar opening rings are destroyed along with the walls of the septa. The most commonly used measurement of airspace enlargement in emphysema is the mean linear intercept (MLI). MLI can be estimated by direct linear measurement from one interalveolar septum to the next adjacent septum and is very dependent on the degree of inflation of the lung. We defined a new design-based measurement called the mean face length (MFL) of interalveolar septa that is not influenced by the degree of inflation. This is a tissue measurement that measures the distance from one interalveolar septal junction (corner of an alveolus) to the adjacent septal junction (adjacent alveolar corner). In normal lung, MFL is highly correlated with alveolar number and volume, while MLI is not. MFL also differentiates differences between normal and elastase-induced emphysema mice better than MLI. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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