| Autor: |
Maiko Hamada |
| Předmět: |
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| Zdroj: |
Synthesis; Jul2007, Vol. 2007 Issue 13, p1927-1929, 3p |
| Abstrakt: |
A practical and concise synthesis of KRP-203 ( 1) was achieved by utilizing a palladium coupling reaction mediated by XantPhos and Pd 2(dba) 3as the key step. The coupling reaction of aryl bromide 5 with 3-hydroxythiophenol ( 6) proceeded chemoselectively to give phenol 7 in spite of the presence of a chlorine substituent on 5 and a hydroxyl group on 6. Phenol 7 was converted into KRP-203 by benzylation and removal of the protecting groups in high yield. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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