| Autor: |
Skoblov, Yuri S., Karpenko, Inna L., Jasko, Maxim V., Kukhanova, Marina K., Andronova, Valery L., Galegov, Georgy A., Sidorov, Georgy V., Myasoedov, Nicolai F. |
| Předmět: |
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| Zdroj: |
Chemical Biology & Drug Design; Jun2007, Vol. 69 Issue 6, p429-434, 6p, 3 Charts, 4 Graphs |
| Abstrakt: |
The combinational use of acyclovir (ACV) phosphonate esters and α2-interferon was shown to produce a synergistic effect on inhibition of HSV-1 replication in Vero cell cultures. Unlike other acyclovir phosphonate derivatives studied earlier, ACV H-phosphonate is not an ACV prodrug. On penetrating into the cells, it may be directly converted into ACV monophosphate escaping dephosphonylation–phosphorylation steps. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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